ABSTRACT
The development and implementation of safe and effective vaccines to prevent the enormous health burden of rotavirus-associated disease is a global public health goal. Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Ten VP7 serotypes and 7 VP4 serotypes have so far been detected. An increasing number of observations, obtained from analyses of (i) natural rotavirus infections in infants and young children, (ii) experimental rotavirus infections in laboratory animals, and (iii) extensive rotavirus vaccine field trials performed in different populations of various parts of the world, appears to support the concept that serotype-specific antibodies to rotaviruses play an important role in protection against rotavirus-associated illnesses. Thus, the first licensed rotavirus vaccine (RRV-based quadrivalent vaccine) was designed to cover the epidemiologically important VP7 serotype 1, 2, 3, and 4.
Subject(s)
Antibodies, Viral/immunology , Child , Child, Preschool , Diarrhea, Infantile/epidemiology , Epitopes/analysis , Female , Genotype , Humans , Immunization , Infant , Infant, Newborn , Male , Rotavirus/classification , Rotavirus Infections/epidemiology , Rotavirus Vaccines , SerotypingABSTRACT
Se estudian los microorganismos enteropatogenos relacionados a diarrea aguda del lactante en muestras de heces tomadas al azar a lo largo de un periodo de 7 meses, durante el ano de 1979, encontrandose E. coli enteroxigenico (14,4%), rotavirus (9,2%) y shigelas (2,6%), en un grupo de 76 ninos.Dentro de este mismo grupo de 25 ninos (8%) y 1 de 25(4%) mostraron ascaris y amebas respectivamente.Los rotavirus se encontraron solo en los meses frios. Los E. coli enterotoxigenicos tanto en los meses frios como calidos. En el 73, 8% de los casos no pudo aislarse un microorganismo sugerente de enteropatogenicidad